256 LIVER GLUCONEOGENESIS REGULATION BY TNFα
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چکیده
منابع مشابه
Regulation of gluconeogenesis and lipogenesis. The regulation of mitochondrial pyruvate metabolism in guinea-pig liver synthesizing precursors for gluconeogenesis.
1. The carboxylation of pyruvate to oxaloacetate by pyruvate carboxylase in guinea-pig liver mitochondria was determined by measuring the amount of (14)C from H(14)CO(3) (-) fixed into organic acids in the presence of pyruvate, ATP, Mg(2+) and P(i). The main products of pyruvate carboxylation were malate, fumarate and citrate. Pyruvate utilization, metabolite formation and incorporation of (14)...
متن کاملCelecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats.
BACKGROUND/AIMS The main purpose of this study was to investigate the effects of celecoxib and ibuprofen, both non-steroidal anti-inflammatory drugs (NSAIDs), on the decreased gluconeogenesis observed in liver of Walker-256 tumor-bearing rats. METHODS Celecoxib and ibuprofen (both at 25 mg/Kg) were orally administered for 12 days, beginning on the same day when the rats were inoculated with W...
متن کاملInhibition of gluconeogenesis by butylmalonate in perfused rat liver.
The role of mitochondrial anion exchange reactions in the control of gluconeogenesis in perfused livers from fasted rats was investigated by using Z-n-butylmalonate to inhibit malate transport across the mitochondrial membrane. Glucose production from pyruvate or lactate was inhibited 50% to 80% by 5 m&r butylmalonate. Oleate (0.5 or 1.5 mr+r) increased glucose production from pyruvate from 82 ...
متن کاملA Site of Regulation of Hepatic Gluconeogenesis by Glucagon*
The effect of glucagon on the rate of gluconeogenesis from substrates not involving pathways of mitochondrial metabolism has been investigated in isolated rat liver cells. From estimation of the rates of glucose formation, glucose phosphorylation, fructose 6-phosphate phosphorylation, fructose 1,6diphosphate dephosphorylation, and lactate and pyruvate formation, it is concluded that glucagon st...
متن کاملControl of Gluconeogenesis in Rat Liver Cells
Control of gluconeogenesis from lactate was studied by titrating rat liver cells with lactate and pyruvate in a ratio of 1 O : l in a perifusion system. At different steady states of glucose formation, the concentration of key gluconeogenic intermediates was measured and plotted against gluconeogenic flux (Jglucoee). Complete saturation was observed only in the plot relating JglUcto the extrace...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1994
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199407000-00256